NDLI: Oxidative Stress, Antioxidants and Hypertension.

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Oxidative Stress, Antioxidants and Hypertension.

Content Provider	Europe PMC
Author	Amponsah-Offeh, Michael Diaba-Nuhoho, Patrick Speier, Stephan Morawietz, Henning
Editor	Hernández, Isabel Más, María Teresa Llinas
Copyright Year	2023
Abstract	As a major cause of morbidity and mortality globally, hypertension remains a serious threat to global public health. Despite the availability of many antihypertensive medications, several hypertensive individuals are resistant to standard treatments, and are unable to control their blood pressure. Regulation of the renin-angiotensin-aldosterone system (RAAS) controlling blood pressure, activation of the immune system triggering inflammation and production of reactive oxygen species, leading to oxidative stress and redox-sensitive signaling, have been implicated in the pathogenesis of hypertension. Thus, besides standard antihypertensive medications, which lower arterial pressure, antioxidant medications were tested to improve antihypertensive treatment. We review and discuss the role of oxidative stress in the pathophysiology of hypertension and the potential use of antioxidants in the management of hypertension and its associated organ damage.
Journal	Antioxidants (Basel, Switzerland)
Volume Number	12
PubMed Central reference number	PMC9952760
Issue Number	2
PubMed reference number	36829839
e-ISSN	20763921
DOI	10.3390/antiox12020281
Language	English
Publisher	MDPI
Publisher Date	2023-01-27
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	hypertension cardiovascular diseases oxidative stress reactive oxygen species antioxidants antihypertensive therapy
Content Type	Text
Resource Type	Article
Subject	Biochemistry Cell Biology Molecular Biology Physiology Clinical Biochemistry Food Science

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