Research Note: Dietary resveratrol supplementation improves the hepatic antioxidant capacity and attenuates lipopolysaccharide-induced inflammation in yellow-feathered broilers.

Content Provider	Europe PMC
Author	Zhu, Cui Nie, Xiaoyan He, Zhentao Xiong, Taidi Li, Yaojie Bai, Yinshan Zhang, Huihua
Copyright Year	2023
Abstract	This experiment investigated the protective effect of resveratrol (RES) on the hepatic antioxidant status and systemic inflammation in yellow-feathered broilers challenged with lipopolysaccharide (LPS). A total of 240 healthy 1-day-old yellow-feathered broilers were randomly divided into 4 groups (control, LPS, RES, and RES+LPS), with 5 replicates of 12 chickens per replicate. The experiment lasted 21 d. The broilers were fed with either the basal diet or the basal diet supplemented with 400 mg/kg RES followed by intraperitoneal challenge with LPS (1 mg/kg body weight) or the same amount of saline at d 16, 18, and 20. The results showed that dietary RES supplementation could improve the activities of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in the liver of yellow-feathered broilers challenged with LPS (P < 0.05). Furthermore, LPS challenge increased the plasma interleukin-17 (IL-17) concentration, the hepatic interleukin-6 (IL-6) and interleukin-1β (IL-1β) concentrations, as well as the concentrations of tumor necrosis factor (TNF-α), IL-6, and IL-1β in the spleen (P < 0.05), and decreased the transforming growth factor-β (TGF-β) concentrations in the plasma, liver, and spleen (P < 0.05). However, dietary RES supplementation could reduce the increased TNF-α levels in the plasma, liver, and spleen induced by LPS, and increased TGF-β level in the liver and spleen (P < 0.05). Collectively, these results suggest that dietary RES supplementation could effectively improve the hepatic antioxidant capacity and attenuate LPS-induced inflammation in yellow-feathered broilers during the starter stage.
ISSN	00325791
Volume Number	102
PubMed Central reference number	PMC9947393
Issue Number	4
PubMed reference number	36774711
Journal	Poultry Science [Poult. Sci]
e-ISSN	15253171
DOI	10.1016/j.psj.2022.102370
Language	English
Publisher	Elsevier
Publisher Date	2022-11-30
Access Restriction	Open
Rights License	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). © 2023 Published by Elsevier Inc. on behalf of Poultry Science Association Inc.
Subject Keyword	yellow-feathered broiler resveratrol lipopolysaccharide antioxidant capacity inflammation
Content Type	Text
Resource Type	Article
Subject	Medicine Animal Science and Zoology