NDLI: Preparation, Drug Distribution, and In Vivo Evaluation of the Safety of Protein Corona Liposomes for Liraglutide Delivery.

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Preparation, Drug Distribution, and In Vivo Evaluation of the Safety of Protein Corona Liposomes for Liraglutide Delivery.

Content Provider	Europe PMC
Author	Ding, Ruihuan Zhao, Zhenyu He, Jibiao Tao, Yuping Zhang, Houqian Yuan, Ranran Sun, Kaoxiang Shi, Yanan
Editor	Kaluđerović, Goran Pantelić, Nebojša
Copyright Year	2023
Abstract	The development of oral drug delivery systems is challenging, and issues related to the mucus layer and low intestinal epithelial permeability have not yet been surmounted. The purpose of this study was to develop a promising formulation that is more adapted to in vivo absorption and to facilitate the administration of oral liraglutide. Cationic liposomes (CLs) linked to AT-1002 were prepared using a double-emulsion method, and BSA was adsorbed on the surface of the AT-CLs, resulting in protein corona cationic liposomes with AT-1002 (Pc-AT-CLs). The preparation method was determined by investigating various process parameters. The particle size, potential, and encapsulation efficiency (EE%) of the Pc-AT-CLs were 202.9 ± 12.4 nm, 1.76 ± 4.87 mV, and 84.63 ± 5.05%, respectively. The transmission electron microscopy (TEM) imaging revealed a nearly spherical structure of the Pc-AT-CLs, with a recognizable coating. The circular dichroism experiments confirmed that the complex preparation process did not affect the secondary structure of liraglutide. With the addition of BSA and AT-1002, the mucosal accumulation of the Pc-AT-CLs was nearly two times lower than that of the AT-CLs, and the degree of enteric metaplasia was 1.35 times higher than that of the PcCLs. The duration of the intestinal absorption of the Pc-AT-CLs was longer, offering remarkable biological safety.
Journal	Nanomaterials (Basel, Switzerland)
Volume Number	13
PubMed Central reference number	PMC9920406
Issue Number	3
PubMed reference number	36770503
e-ISSN	20794991
DOI	10.3390/nano13030540
Language	English
Publisher	MDPI
Publisher Date	2023-01-29
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	liposome oral drug delivery systems osmoregulatory peptide mucus layers intestinal epithelial permeability
Content Type	Text
Resource Type	Article
Subject	Chemical Engineering Materials Science

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