Latilactobacillus sakei Wikim0066 Protects Skin through MMP Regulation on UVB-Irradiated In Vitro and In Vivo Model.

Content Provider	Europe PMC
Author	Park, Jeong-Yong Lee, Ji Yeon Kim, YongGyeong Kang, Chang-Ho
Editor	Ohkusa, Toshifumi
Copyright Year	2023
Abstract	Ultraviolet (UV) B exposure induces wrinkle formation, collagen fiber breakdown, and transepidermal water loss (TEWL). UVB irradiation induces the expression of mitogen-activated protein kinase (MAPK), activator protein 1 (AP-1), and nuclear factor kappa B (NF-κB), which affect the expression of matrix metalloproteinases (MMP). We confirmed the effects of Latilactobacillus sakei wikim0066 (wikim0066) on UVB-irradiated Hs68 cells and HR-1 hairless mice cells. wikim0066 restored the production of type I procollagen by regulating the expression of MMP-1 and -3, MAPK, AP-1, and NF-κB in UVB-irradiated Hs68 cells and HR-1 mice. Oral administration of wikim0066 alleviates wrinkle formation, epidermal thickness, and TEWL in UVB-irradiated HR-1 hairless mice. These results indicated that wikim0066 has the potential to prevent UVB-induced wrinkle formation.
Journal	Nutrients
Volume Number	15
PubMed Central reference number	PMC9919521
Issue Number	3
PubMed reference number	36771432
e-ISSN	20726643
DOI	10.3390/nu15030726
Language	English
Publisher	MDPI
Publisher Date	2023-02-01
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2023 by the authors.
Subject Keyword	wrinkle ultraviolet B collagen matrix metalloproteinase Latilactobacillus sakei
Content Type	Text
Resource Type	Article
Subject	Food Science Nutrition and Dietetics