Immunostimulatory effects of dairy probiotic strains Bifidobacterium animalis ssp. lactis HY8002 and Lactobacillus plantarum HY7717.

Content Provider	Europe PMC
Author	Kim, Ju-Yeon Kim, Joo Yun Kim, Hyeonji Moon, Eun Chae Heo, Keon Shim, Jae-Jung Lee, Jung-Lyoul
Copyright Year	2022
Abstract	AbstractPrevious studies reported that Bifidobacterium animalis ssp.lactis HY8002 (HY8002) improved intestinal integrity andhad immunomodulatory effects. Lactobacillus plantarum HY7717(HY7717) was screened in vitro from among 21 other lactic acidbacteria (LAB) and demonstrated nitric oxide (NO) production. The aims of thisstudy were to investigate the individual and combined ex vivo and in vivo effects of LAB strains HY8002 and HY7717 atimmunostimulating mice that have been challenged with an immunosuppressant drug.The combination of HY8002 and HY7717 increased the secretion of cytokines suchas interferon (IFN)-γ, interleukin (IL)-12, and tumor necrosis factor(TNF)-α in splenocytes. In a cyclophosphamide (CTX)-inducedimmunosuppression model, administration of the foregoing LAB combinationimproved the splenic and hematological indices, activated natural killer (NK)cells, and up-regulated plasma immunoglobulins and cytokines. Moreover, thiscombination treatment increased Toll-like receptor 2 (TLR2) expression. Theability of the combination treatment to upregulate IFN-γ and TNF-αin the splenocytes was inhibited by anti-TLR2 antibody. Hence, the immuneresponses stimulated by the combination of HY8002 and HY7717 are associated withTLR2 activation. The preceding findings suggest that the combination of theHY8002 and HY7717 LAB strains could prove to be a beneficial and efficaciousimmunostimulant probiotic supplement. The combination of the two probioticstrains will be applied on the dairy foods including yogurt and cheese.
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ISSN	26720191
Journal	Journal of Animal Science and Technology [J Anim Sci Technol]
Volume Number	64
DOI	10.5187/jast.2022.e84
PubMed Central reference number	PMC9890336
Issue Number	6
PubMed reference number	36812033
e-ISSN	20550391
Language	English
Publisher	Korean Society of Animal Sciences and Technology
Publisher Date	2022-11-30
Access Restriction	Open
Rights License	This is an Open-Access article distributed under the terms of theCreative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permitsunrestricted non-commercial use, distribution, and reproduction in anymedium, provided the original work is properly cited. © Copyright 2022 Korean Society of Animal Science andTechnology
Subject Keyword	Immune Immunostimulation Cytokines Toll-like receptor Cyclophosphamide
Content Type	Text
Resource Type	Article
Subject	Ecology Veterinary Biochemistry, Genetics and Molecular Biology Animal Science and Zoology Food Science