Prognostic factors for cancer-specific survival in 220 patients with breast cancer: A single center experience.

Content Provider	Europe PMC
Author	Tarlan, Mitra Khazaei, Sedigheh Madani, Seyed Hamid Saleh, Elaheh
Abstract	AbstractObjectivesHospital‐based breast cancer survival studies are scarce in western Iran. Furthermore, the relationship between breast cancer survival and clinical parameters has been extensively studied, but many of the findings come from developing countries. This paper aims to estimate the survival of hospital‐based breast cancer patients and its predictor factors.MethodThis retrospective analysis was conducted on 578 patients with primary breast cancer who underwent surgery between 2004 and 2020. Information was collected from medical reports by the Hospital information system in Imam Reza Hospital, Kermanshah, Iran. One‐, 2‐, 5‐, and 10‐year breast cancer‐specific survival has been calculated using the Kaplan–Meier process. Crude and adjusted Hazard Ratios (HR) were calculated using the Cox proportional regression model.ResultOne‐, 2‐, and 5‐year overall breast cancer survival were 219 (99.54%), 196 (89.09%), 159 (72.27%), and 70 (31.81%), respectively. Univariate analysis of breast cancer patients with tumor‐related variables revealed that factors such as age, menopause status, lymph node metastasis, number of lymph nodes, organ metastasis, and stage of disease were significantly associated with disease‐specific survival (p < .05). Multivariate analysis demonstrated that metastasis (HR = 41.77, 95% CI: 15.3–114.15) and lymph node metastasis (HR = 5.26, 95% CI: 1.9–14.6) were significantly related to survival.ConclusionThe findings demonstrate that survival is relatively low and is consistent with late‐stage disease diagnosis. It is believed that this is due to a poor level of awareness, lack of screening programs, and subsequent late access to treatment.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9875637&blobtype=pdf
Page Count	10
Journal	Cancer Reports [Cancer Rep (Hoboken)]
Volume Number	6
DOI	10.1002/cnr2.1675
PubMed Central reference number	PMC9875637
Issue Number	1
PubMed reference number	35931659
e-ISSN	25738348
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-08-05
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2022 The Authors. Cancer Reports published by Wiley Periodicals LLC.
Subject Keyword	breast cancer breast cancer prognosis factors clinical parameters retrospective analysis
Content Type	Text
Resource Type	Article
Subject	Oncology Cancer Research