NDLI: The Association between Brain-Derived Neurotrophic Factor (BDNF) Protein Level and Body Mass Index.

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The Association between Brain-Derived Neurotrophic Factor (BDNF) Protein Level and Body Mass Index.

Content Provider	Europe PMC
Author	Taha, Murtada A. AL-maqati, Thekra N. Alnaam, Yaser A. Alharbi, Sulaiman S. Khaneen, Rajaa Almutairi, Hajra AL-harbi, Mashael
Editor	Rizzo, Manfredi
Copyright Year	2022
Abstract	Background and Objectives: Obesity is a major health concern worldwide. Many studies emphasize the important role of brain-derived neurotrophic factor (BDNF) in regulating appetite and body weight. We aimed to investigate the association between BDNF protein serum levels and body mass index (BMI). Materials and Methods: We conducted a cross-sectional study among 108 healthy adult participants divided into six categories depending on their body mass index (BMI). The ages of the participants ranged between 21 to 45 years. The BDNF serum level was measured using the enzyme-linked immunosorbent assay (ELISA) technique. Results: A Kruskal–Wallis test showed a significant difference in BDNF between the different BMI categories, χ2(2) = 24.201, p < 0.001. Our data also showed that BDNF levels were significantly lower in people with obesity classes II and III than those of normal weight (p < 0.05). The Spearman rank correlation test was statistically significant with negative correlations between the BMI and BDNF (r) = −0.478, (p < 0.01). Moreover, we observed a negative dose-dependent relationship pattern between BMI categories and the levels of circulating BDNF protein. Conclusions: In this study, our data support the hypothesis that low serum levels of BDNF are associated with high BMI and obesity in Saudi adults.
ISSN	1010660X
Journal	Medicina (Kaunas, Lithuania)
Volume Number	59
PubMed Central reference number	PMC9865735
Issue Number	1
PubMed reference number	36676721
e-ISSN	16489144
DOI	10.3390/medicina59010099
Language	English
Publisher	MDPI
Publisher Date	2022-12-31
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	brain-derived neurotrophic factor (BDNF) body mass index (BMI) obesity Serum BDNF adult
Content Type	Text
Resource Type	Article
Subject	Medicine

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