Metal-Free One-Pot Multi-Functionalization of Unsaturated Compounds with Interelement Compounds by Radical Process.

Content Provider	Europe PMC
Author	Yamamoto, Yuki Ogawa, Akiya
Editor	Soloshonok, Vadim A. Dembinski, Roman
Copyright Year	2023
Abstract	In recent years, the importance of "environmentally friendly manufacturing" has been increasing toward the establishment of a resource-recycling society. In organic synthesis, as well, it is becoming increasingly important to develop new synthetic strategies with resource conservation and the recycling of elemental resources in mind, rather than just only synthesis. Many studies on the construction of frameworks of functional molecules using ionic reactions and transition-metal-catalyzed reactions have been reported, but most of them have focused on the formation of carbon-carbon bonds. However, it is essential to introduce appropriate functional groups at appropriate positions in molecules in order for the molecules to express their functions, and furthermore, the highly selective preparation of multiple functional groups is considered important for the creation of new functional molecules. In this review, we focus on radical reactions with high functional group selectivity and overview the recent progress in practical methods for the simultaneous introduction of multiple functional groups and propose future synthetic strategies that emphasize the recycling of elemental resources and environmental friendliness.
Journal	Molecules
Volume Number	28
DOI	10.3390/molecules28020787
PubMed Central reference number	PMC9861539
Issue Number	2
PubMed reference number	36677845
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-01-12
Access Restriction	Open
Subject Keyword	heteroatoms interelement compounds metal-free conditions radical reaction unsaturated compounds functionalization
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry