NDLI: Biological Secondary Metabolites from the Lumnitzera littorea-Derived Fungus Penicillium oxalicum HLLG-13

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Biological Secondary Metabolites from the Lumnitzera littorea-Derived Fungus Penicillium oxalicum HLLG-13

Content Provider	Europe PMC
Author	Wang, Yue Chen, Wenhao Xu, Zhefei Bai, Qiqi Zhou, Xueming Zheng, Caijuan Bai, Meng Chen, Guangying
Editor	Luo, Xiaowei Gao, Chenghai Zhou, Xuefeng
Copyright Year	2022
Abstract	Five new compounds, including two cyclopiane diterpenes conidiogenones J and K (1–2), a steroid andrastin H (5), an alkaloid (Z)-4-(5-acetoxy-N-hydroxy-3-methylpent-2-enamido) butanoate (6), and an aliphatic acid (Z)-5-acetoxy-3-methylpent-2-enoic acid (7), together with ten known compounds (3–4 and 8–15) were isolated from the EtOAc extract of the fermentation broth of the Lumnitzera littorea-derived fungus Penicillium oxalicum HLLG-13. Their structures were elucidated by 1D, 2D NMR, and HR-ESI-MS spectral analyses. The absolute configurations of 1, 2, 5, and 8 were determined by quantum chemical electronic circular dichroism (ECD) calculations, and the absolute configuration of 8 was determined for the first time. Compound 15 was a new natural product, and its NMR data were reported for the first time. Compounds 5 and 9–14 exhibited antibacterial activities against Staphylococcus epidermidis and Candida albicans, with MIC values ranging from 6.25 to 25 μg/ mL. Compounds 1–6 and 9–14 showed significant growth inhibition activities against newly hatched Helicoverpa armigera Hubner larvae, with IC50 values ranging from 50 to 200 μg/mL.
Journal	Marine Drugs
Volume Number	21
PubMed Central reference number	PMC9860879
Issue Number	1
PubMed reference number	36662195
e-ISSN	16603397
DOI	10.3390/md21010022
Language	English
Publisher	MDPI
Publisher Date	2022-12-27
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	Lumnitzera littorea Penicillium oxalicum secondary metabolites biological activity
Content Type	Text
Resource Type	Article
Subject	Pharmacology, Toxicology and Pharmaceutics Drug Discovery Pharmaceutical Science

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