NDLI: The Emerging Role of Menstrual-Blood-Derived Stem Cells in Endometriosis.

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The Emerging Role of Menstrual-Blood-Derived Stem Cells in Endometriosis.

Content Provider	Europe PMC
Author	Cordeiro, Mariana Robalo Carvalhos, Carlota Anjinho Figueiredo-Dias, Margarida
Editor	Machairiotis, Nikolaos
Copyright Year	2022
Abstract	The human endometrium has a complex cellular composition that is capable of promoting cyclic regeneration, where endometrial stem cells play a critical role. Menstrual blood-derived stem cells (MenSC) were first discovered in 2007 and described as exhibiting mesenchymal stem cell properties, setting them in the spotlight for endometriosis research. The stem cell theory for endometriosis pathogenesis, supported by the consensual mechanism of retrograde menstruation, highlights the recognized importance that MenSC have gained by potentially being directly related to the genesis, development and maintenance of ectopic endometriotic lesions. Meanwhile, the differences observed between MenSC in patients with endometriosis and in healthy women underlines the applicability of these cells as a putative biomarker for the early diagnosis of endometriosis, as well as for the development of targeted therapies. It is expected that in the near future MenSC will have the potential to change the way we manage this complex disease, once their long-term safety and effectiveness are assessed.
Journal	Biomedicines
Volume Number	11
PubMed Central reference number	PMC9856091
Issue Number	1
PubMed reference number	36672546
e-ISSN	22279059
DOI	10.3390/biomedicines11010039
Language	English
Publisher	MDPI
Publisher Date	2022-12-24
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	menstrual-blood-derived stem cells endometriosis early diagnosis pathophysiology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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