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Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals.
| Content Provider | Europe PMC |
|---|---|
| Author | Perkiö, Anna Merikanto, Ilona Kantojärvi, Katri Paunio, Tiina Sinnott-Armstrong, Nasa Jones, Samuel E. Ollila, Hanna M. |
| Editor | Khalyfa, Abdelnaby |
| Copyright Year | 2022 |
| Abstract | Polygenic risk scores (PRSs) estimate genetic liability for diseases and traits. However, the portability of PRSs in sleep traits has remained elusive. We generated PRSs for self-reported insomnia, chronotype and sleep duration using summary data from genome-wide association studies (GWASs) performed in 350,000 to 697,000 European-ancestry individuals. We then projected the scores in two independent Finnish population cohorts (N = 33,493) and tested whether the PRSs were associated with their respective sleep traits. We observed that all the generated PRSs were associated with their corresponding traits (p < 0.05 in all cases). Furthermore, we found that there was a 22.2 min difference in reported sleep between the 5% tails of the PRS for sleep duration (p < 0.001). Our findings indicate that sleep-related PRSs show portability across cohorts. The findings also demonstrate that sleep measures using PRSs for sleep behaviors may provide useful instruments for testing disease and trait associations in cohorts where direct sleep parameters have not yet been measured. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9844282&blobtype=pdf |
| Journal | Clocks & Sleep |
| Volume Number | 5 |
| DOI | 10.3390/clockssleep5010002 |
| PubMed Central reference number | PMC9844282 |
| Issue Number | 1 |
| PubMed reference number | 36648941 |
| e-ISSN | 26245175 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-12-30 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors. |
| Subject Keyword | circadian rhythms eveningness insomnia symptoms morningness polygenic score PRS |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neuroscience |
