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Tissue-engineered tendon nano-constructs for repair of chronic rotator cuff tears in large animal models.
| Content Provider | Europe PMC |
|---|---|
| Author | Gwon, Yonghyun Kim, Woochan Park, Sunho Kim, Yang‐Kyung Kim, Hyoseong Kim, Myung‐Sun Kim, Jangho |
| Abstract | AbstractChronic rotator cuff tears (RCTs) are one of the most common injuries of shoulder pain. Despite the recent advances in surgical techniques and improved clinical outcomes of arthroscopically repaired rotator cuffs (RCs), complete functional recovery—without retear—of the RC tendon through tendon‐to‐bone interface (TBI) regeneration remains a key clinical goal to be achieved. Inspired by the highly organized nanostructured extracellular matrix in RC tendon tissue, we propose herein a tissue‐engineered tendon nano‐construct (TNC) for RC tendon regeneration. When compared with two currently used strategies (i.e., transosseous sutures and stem cell injections), our nano‐construct facilitated more significant healing of all parts of the TBI (i.e., tendon, fibrocartilages, and bone) in both rabbit and pig RCT models owing to its enhancements in cell proliferation and differentiation, protein expression, and growth factor secretion. Overall, our findings demonstrate the high potential of this transplantable tendon nano‐construct for clinical repair of chronic RCTs. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9842040&blobtype=pdf |
| Page Count | 14 |
| Journal | Bioengineering & Translational Medicine [Bioeng Transl Med] |
| Volume Number | 8 |
| DOI | 10.1002/btm2.10376 |
| PubMed Central reference number | PMC9842040 |
| Issue Number | 1 |
| PubMed reference number | 36684112 |
| e-ISSN | 23806761 |
| Language | English |
| Publisher | John Wiley & Sons, Inc. |
| Publisher Date | 2022-07-22 |
| Publisher Place | Hoboken, USA |
| Access Restriction | Open |
| Rights License | This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. |
| Subject Keyword | chronic rotator cuff tears large animal model tendon nano‐construct tendon regeneration tendon‐to‐bone interface |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biotechnology Pharmaceutical Science Biomedical Engineering |
