Uric acid relationships with lipid profile and adiposity indices: Impact of different hyperuricemic thresholds.

Content Provider	Europe PMC
Author	Maloberti, Alessandro Vanoli, Jennifer Finotto, Alessandra Bombelli, Michele Facchetti, Rita Redon, Pau Mancia, Giuseppe Grassi, Guido
Abstract	AbstractPrevious studies focused on the relationships between Serum Uric Acid (SUA) and lipids have found an association mainly with triglycerides. Furthermore, previous studies on adiposity indices have been focused on the evaluation of the Visceral Adiposity Index (VAI). The present study was aimed at providing within the same population a systematic evaluation of lipids and adiposity indices with SUA, employing both the classic cutoff for hyperuricemia and the newly one identified by the Uric Acid Right for Heart Health (URRAH) study. We analyzed data collected in 1892 subjects of the Pressioni Arteriose Monitorate E loro Associazioni (PAMELA) study with available SUA, lipid profile and variables necessary to calculate VAI, Cardio‐Metabolic Index (CMI) and Lipid Accumulation Product (LAP). At linear regression model (corrected for confounders) SUA correlated with all the lipids values (with the strongest β for triglycerides) and adiposity indices. When the two different cutoffs were compared, the URRAH one was significantly related to atherogenic lipids profile (OR 1.207 for LDL and 1.33 for non‐HDL, P < 0.001) while this was not the case for the classic one. Regarding adiposity indices the classic cutoff displays highest OR as compared to the URRAH one. In conclusions, newly reported URRAH cutoff for hyperuricemia better relate to atherogenic lipoprotein (LDL and non‐HDL) when compared to the classic one. The opposite has been found for adiposity indexes where the classic cut‐off seems to present highest performance. Among adiposity indexes, LAP present the highest OR for the relationship with hyperuricemia.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9832232&blobtype=pdf
Page Count	8
ISSN	15246175
Journal	The Journal of Clinical Hypertension [J Clin Hypertens (Greenwich)]
Volume Number	25
DOI	10.1111/jch.14613
PubMed Central reference number	PMC9832232
Issue Number	1
PubMed reference number	36573350
e-ISSN	17517176
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-12-27
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2022 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.
Subject Keyword	adiposity indices cardiometabolic index lipid accumulation product lipids uric acid visceral adiposity index
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Cardiology and Cardiovascular Medicine