MR multitasking-based dynamic imaging for cerebrovascular evaluation (MT-DICE): Simultaneous quantification of permeability and leakage-insensitive perfusion by dynamic T 1 / T 2 * mapping.

Content Provider	Europe PMC
Author	Hu, Zhehao Christodoulou, Anthony G. Wang, Nan Xie, Yibin Shiroishi, Mark S. Yang, Wensha Zada, Gabriel Chow, Frances E. Margol, Ashley S. Tamrazi, Benita Chang, Eric L. Li, Debiao Fan, Zhaoyang
Abstract	PurposeTo develop an MR multitasking‐based dynamic imaging for cerebrovascular evaluation (MT‐DICE) technique for simultaneous quantification of permeability and leakage‐insensitive perfusion with a single‐dose contrast injection.MethodsMT‐DICE builds on a saturation‐recovery prepared multi‐echo fast low‐angle shot sequence. The k‐space is randomly sampled for 7.6 min, with single‐dose contrast agent injected 1.5 min into the scan. MR multitasking is used to model the data into six dimensions, including three spatial dimensions for whole‐brain coverage, a saturation‐recovery time dimension, and a TE dimension for dynamic T1 and T2* quantification, respectively, and a contrast dynamics dimension for capturing contrast kinetics. The derived pixel‐wise T1/T2* time series are converted into contrast concentration‐time curves for calculation of kinetic metrics. The technique was assessed for its agreement with reference methods in T1 and T2* measurements in eight healthy subjects and, in three of them, inter‐session repeatability of permeability and leakage‐insensitive perfusion parameters. Its feasibility was also demonstrated in four patients with brain tumors.ResultsMT‐DICE T1/T2* values of normal gray matter and white matter were in excellent agreement with reference values (intraclass correlation coefficients = 0.860/0.962 for gray matter and 0.925/0.975 for white matter ). Both permeability and perfusion parameters demonstrated good to excellent intersession agreement with the lowest intraclass correlation coefficients at 0.694. Contrast kinetic parameters in all healthy subjects and patients were within the literature range.ConclusionBased on dynamic T1/T2* mapping, MT‐DICE allows for simultaneous quantification of permeability and leakage‐insensitive perfusion metrics with a single‐dose contrast injection.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9826278&blobtype=pdf
Page Count	16
ISSN	07403194
Journal	Magnetic Resonance in Medicine [Magn Reson Med]
Volume Number	89
DOI	10.1002/mrm.29431
PubMed Central reference number	PMC9826278
Issue Number	1
PubMed reference number	36128892
e-ISSN	15222594
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-09-21
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
Subject Keyword	brain tumors DCE‐MR DSC‐MR MR multitasking perfusion permeability
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging