A Near-Infrared Fluorescent Probe for Recognition of Hypochlorite Anions Based on Dicyanoisophorone Skeleton.

Content Provider	Europe PMC
Author	Liu, Chang-Xiang Xiao, Shu-Yuan Gong, Xiu-Lin Zhu, Xi Wang, Ya-Wen Peng, Yu
Editor	Zhang, Yuanwei Huang, Ling
Copyright Year	2023
Abstract	A novel near-infrared (NIR) fluorescent probe (SWJT-9) was designed and synthesized for the detection of hypochlorite anion (ClO-) using a diaminomaleonitrile group as the recognition site. SWJT-9 had large Stokes shift (237 nm) and showed an excellent NIR fluorescence response to ClO- with the color change under the visible light. It showed a low detection limit (24.7 nM), high selectivity, and rapid detection (within 2 min) for ClO-. The new detection mechanism of SWJT-9 on ClO- was confirmed by 1H NMR, MS spectrum, and the density functional theory (DFT) calculations. In addition, the probe was successfully used to detect ClO- in HeLa cells.
Journal	Molecules
Volume Number	28
DOI	10.3390/molecules28010402
PubMed Central reference number	PMC9823594
Issue Number	1
PubMed reference number	36615593
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2023-01-03
Access Restriction	Open
Subject Keyword	fluorescence hypochlorite anion (ClO−) near-infrared probe chemodosimeter
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry