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Myocardial scar detection in free-breathing Dixon-based fat- and water-separated 3D inversion recovery late-gadolinium enhancement whole heart MRI.
| Content Provider | Europe PMC |
|---|---|
| Author | Peters, Alan A. Wagner, Benedikt Spano, Giancarlo Haupt, Fabian Ebner, Lukas Kunze, Karl-Philipp Schmidt, Michaela Neji, Radhouene Botnar, René Prieto, Claudia Jung, Bernd Christe, Andreas Gräni, Christoph Huber, Adrian T. |
| Abstract | The aim of this study was to investigate the diagnostic accuracy and reader confidence for late-gadolinium enhancement (LGE) detection of a novel free-breathing, image-based navigated 3D whole-heart LGE sequence with fat–water separation, compared to a free-breathing motion-corrected 2D LGE sequence in patients with ischemic and non-ischemic cardiomyopathy. Cardiac MRI patients including the respective sequences were retrospectively included. Two independent, blinded readers rated image quality, depiction of segmental LGE and documented acquisition time, SNR, CNR and amount of LGE. Results were compared using the Friedman or the Kruskal–Wallis test. For LGE rating, a jackknife free-response receiver operating characteristic analysis was performed with a figure of merit (FOM) calculation. Forty-two patients were included, thirty-two were examined with a 1.5 T-scanner and ten patients with a 3 T-scanner. The mean acquisition time of the 2D sequence was significantly shorter compared to the 3D sequence (07:12 min vs. 09:24 min; p < 0.001). The 3D scan time was significantly shorter when performed at 3 T compared to 1.5 T (07:47 min vs. 09:50 min; p < 0.001). There were no differences regarding SNR, CNR or amount of LGE. 3D imaging had a significantly higher FOM (0.89 vs. 0.78; p < 0.001). Overall image quality ratings were similar, but 3D sequence ratings were higher for fine anatomical structures. Free-breathing motion-corrected 3D LGE with high isotropic resolution results in enhanced LGE-detection with higher confidence and better delineation of fine structures. The acquisition time for 3D imaging was longer, but may be reduced by performing on a 3 T-scanner. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9813059&blobtype=pdf |
| ISSN | 15695794 |
| Journal | The International Journal of Cardiovascular Imaging [Int J Cardiovasc Imaging] |
| Volume Number | 39 |
| DOI | 10.1007/s10554-022-02701-0 |
| PubMed Central reference number | PMC9813059 |
| Issue Number | 1 |
| PubMed reference number | 36598693 |
| e-ISSN | 18758312 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2022-08-23 |
| Publisher Place | Dordrecht |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2022 |
| Subject Keyword | Cardiac Three-dimensional imaging Magnetic resonance imaging Cardiomyopathies Pericardium Myocardium |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Cardiology and Cardiovascular Medicine |
