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Detection of Occult Hepatitis C Virus Infection in Egyptian Patients Who Achieved a Sustained Virologic Response to Direct-Acting Antiviral Agents.
| Content Provider | Europe PMC |
|---|---|
| Author | Mashaal, Ahmed R Abd El-Hameed, Mohamed El Ray, Ahmed A Diab, Tarek Mahmoud Dawood, Reham M Shemis, Mohamed A Seyam, Moataz |
| Abstract | Background:Occult hepatitis C virus (HCV) infection (OCI) is diagnosed based on the detection of HCV-RNA in non-serum reservoirs, such as peripheral blood mononuclear cells (PBMCs) and/or hepatocytes with undetectable HCV-RNA in the serum. The current study was designed to shed more light on the presence of occult HCV in a population of cases who achieved an SVR after receiving treatments for HCV-infection and its significance. Methods:This cross-sectional study evaluated 111 chronic HCV patients treated at Theodor Bilharz Research Institute, Egypt and achieved a sustained virological response (SVR) 12 -24 weeks after treatment with Direct acting antiviral drugs (DAAs). The treatment lasted 12 or 24 weeks using generic medications including Sofosbuvir (SOF) 400 mg/day and Daclatasvir (DCV) 60 mg/day ± weight-based Ribavirin (RBV) 600-1000 mg/day. After achieving the SVR 12 -24 weeks, all patients were subjected to clinical examination and full laboratory investigations. All the candidates were assessed for fibrosis pre/post-treatment by transient elastography (Fibroscan©). Eighty-seven patients (78.4%) received dual therapy (SOF/DCV) and 24 patients (21.6%) received triple therapy (SOF/DCV/RBV). One hundred and seven patients received the regimen for 12 weeks (96.4%) and only four patients received the regimen for 24 weeks (3.6%). All patients were examined in terms of HCV RNA in plasma and PBMCs. Results:Nine patients (8.1%) were positive for PBMCs HCV RNA. The presence of Occult HCV infection (OCI) was significantly correlated with age, level of AFP, and the degree of liver stiffness.Conclusion: The OCI was present in 8.1% of the patients who achieved an SVR 12 – 24 weeks. These patients were mostly aged and with elevated AFP and advanced fibrosis. Monitoring and follow-up of those patients may help to assess the outcomes. |
| ISSN | 15137368 |
| Volume Number | 23 |
| PubMed Central reference number | PMC9810323 |
| Issue Number | 9 |
| PubMed reference number | 36172658 |
| Journal | Asian Pacific Journal of Cancer Prevention : APJCP [Asian Pac. J. Cancer Prev] |
| e-ISSN | 2476762X |
| DOI | 10.31557/APJCP.2022.23.9.2965 |
| Language | English |
| Publisher | West Asia Organization for Cancer Prevention |
| Publisher Date | 2022-09-01 |
| Publisher Place | Iran |
| Access Restriction | Open |
| Rights License | This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. https://creativecommons.org/licenses/by-nc/4.0/ |
| Subject Keyword | Hepatitis C virus (HCV) Occult Hepatitis C Virus Infection (OCI) Direct-Acting Antiviral Agents (DAAs) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Public Health, Environmental and Occupational Health Cancer Research Epidemiology Oncology |
