NDLI: United we stand: Double targeting of CD79B and CD20 in diffuse large B-cell lymphoma.

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United we stand: Double targeting of CD79B and CD20 in diffuse large B-cell lymphoma.

Content Provider	Europe PMC
Author	Tarantelli, Chiara Bertoni, Francesco
Abstract	SummaryPolatuzumab vedotin is antibody‐drug conjugate (ADC) targeting CD79B approved for the treatment of patients with relapsed/refractory diffuse large B‐cell lymphoma when given in combination with bendamustine and rituximab. The report by Kawasaki et al. provide hints on what might be happening in lymphoma cells exposed to polatuzumab vedotin and to rituximab and on potential mechanism of resistance to the ADC.Commentary on: Kawasaki et al. The molecular rationale for the combination of polatuzumab vedotin plus rituximab in diffuse large B‐cell lymphoma. Br J Haematol 2022;199:245‐255.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9804191&blobtype=pdf
Page Count	2
ISSN	00071048
Journal	British Journal of Haematology [Br J Haematol]
Volume Number	199
DOI	10.1111/bjh.18384
PubMed Central reference number	PMC9804191
Issue Number	2
PubMed reference number	35917107
e-ISSN	13652141
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-08-02
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.
Subject Keyword	antibody‐drug conjugate lymphoma MMAE polatuzumab vedotin resistance rituximab
Content Type	Text
Resource Type	Article
Subject	Hematology

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