NDLI: Raman Spectroscopy of Carotenoid Compounds for Clinical Applications-A Review.

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Raman Spectroscopy of Carotenoid Compounds for Clinical Applications-A Review.

Content Provider	Europe PMC
Author	Udensi, Joy Loughman, James Loskutova, Ekaterina Byrne, Hugh J.
Editor	Mavromoustakos, Thomas
Copyright Year	2022
Abstract	Carotenoid compounds are ubiquitous in nature, providing the characteristic colouring of many algae, bacteria, fruits and vegetables. They are a critical component of the human diet and play a key role in human nutrition, health and disease. Therefore, the clinical importance of qualitative and quantitative carotene content analysis is increasingly recognised. In this review, the structural and optical properties of carotenoid compounds are reviewed, differentiating between those of carotenes and xanthophylls. The strong non-resonant and resonant Raman spectroscopic signatures of carotenoids are described, and advances in the use of Raman spectroscopy to identify carotenoids in biological environments are reviewed. Focus is drawn to applications in nutritional analysis, optometry and serology, based on in vitro and ex vivo measurements in skin, retina and blood, and progress towards establishing the technique in a clinical environment, as well as challenges and future perspectives, are explored.
Journal	Molecules
Volume Number	27
DOI	10.3390/molecules27249017
PubMed Central reference number	PMC9784873
Issue Number	24
PubMed reference number	36558154
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2022-12-17
Access Restriction	Open
Subject Keyword	carotenoids beta carotene lycopene lutein zeaxanthin Raman spectroscopy skin optometry blood
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry

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