Cyrene: A Green Solvent for the Synthesis of Bioactive Molecules and Functional Biomaterials.

Content Provider	Europe PMC
Author	Citarella, Andrea Amenta, Arianna Passarella, Daniele Micale, Nicola
Editor	Rimoli, Maria Grazia Frecentese, Francesco
Copyright Year	2022
Abstract	In the panorama of sustainable chemistry, the use of green solvents is increasingly emerging for the optimization of more eco-friendly processes which look to a future of biocompatibility and recycling. The green solvent Cyrene, obtained from biomass via a two-step synthesis, is increasingly being introduced as the solvent of choice for the development of green synthetic transformations and for the production of biomaterials, thanks to its interesting biocompatibility, non-toxic and non-mutagenic properties. Our review offers an overview of the most important organic reactions that have been investigated to date in Cyrene as a medium, in particular focusing on those that could potentially lead to the formation of relevant chemical bonds in bioactive molecules. On the other hand, a description of the employment of Cyrene in the production of biomaterials has also been taken into consideration, providing a point-by-point overview of the use of Cyrene to date in the aforementioned fields.
Journal	International Journal of Molecular Sciences [Int J Mol Sci]
Volume Number	23
DOI	10.3390/ijms232415960
PubMed Central reference number	PMC9783252
Issue Number	24
PubMed reference number	36555601
e-ISSN	14220067
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2022-12-15
Access Restriction	Open
Subject Keyword	cyrene green chemistry green synthesis sustainable chemistry nanomaterials
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications Medicine Inorganic Chemistry Organic Chemistry