NDLI: Co-Infection of the Epstein-Barr Virus and the Kaposi Sarcoma-Associated Herpesvirus.

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Co-Infection of the Epstein-Barr Virus and the Kaposi Sarcoma-Associated Herpesvirus.

Content Provider	Europe PMC
Author	Böni, Michelle Rieble, Lisa Münz, Christian
Editor	He, Bin
Copyright Year	2022
Abstract	The two human tumor viruses, Epstein–Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV), have been mostly studied in isolation. Recent studies suggest that co-infection with both viruses as observed in one of their associated malignancies, namely primary effusion lymphoma (PEL), might also be required for KSHV persistence. In this review, we discuss how EBV and KSHV might support each other for persistence and lymphomagenesis. Moreover, we summarize what is known about their innate and adaptive immune control which both seem to be required to ensure asymptomatic persistent co-infection with these two human tumor viruses. A better understanding of this immune control might allow us to prepare for vaccination against EBV and KSHV in the future.
Journal	Viruses
Volume Number	14
PubMed Central reference number	PMC9782805
Issue Number	12
PubMed reference number	36560713
e-ISSN	19994915
DOI	10.3390/v14122709
Language	English
Publisher	MDPI
Publisher Date	2022-12-02
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	natural killer cells cytotoxic lymphocytes T cells latent and lytic infection B cell lymphomas Kaposi sarcoma humanized mice
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology

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