NDLI: A Review: Meridianins and Meridianins Derivatives.

Content Provider	Europe PMC
Author	Xiao, Linxia
Editor	Kirsch, Gilbert
Copyright Year	2022
Abstract	Meridianins are a family of indole alkaloids derived from Antarctic tunicates with extensive pharmacological activities. A series of meridianin derivatives had been synthesized by drug researchers. This article reviews the extraction and purification methods, biological activities and pharmacological applications, pharmacokinetic characters and chemical synthesis of meridianins and their derivatives. And prospects on discovering new bioactivities of meridianins and optimizing their structure for the improvement of the ADMET properties are provided.
Journal	Molecules
Volume Number	27
DOI	10.3390/molecules27248714
PubMed Central reference number	PMC9781522
Issue Number	24
PubMed reference number	36557848
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2022-12-09
Access Restriction	Open
Subject Keyword	meridianins indole alkaloids biological activities pharmacological applications pharmacokinetic characters chemical synthesis prospects
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry

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