Advancing New Approach Methodologies (NAMs) for Tobacco Harm Reduction: Synopsis from the 2021 CORESTA SSPT-NAMs Symposium.

Content Provider	Europe PMC
Author	Lee, Kyeonghee Monica Corley, Richard Jarabek, Annie M. Kleinstreuer, Nicole Paini, Alicia Stucki, Andreas O. Bell, Shannon
Editor	Benfenati, Emilio
Copyright Year	2022
Abstract	New approach methodologies (NAMs) are emerging chemical safety assessment tools consisting of in vitro and in silico (computational) methodologies intended to reduce, refine, or replace (3R) various in vivo animal testing methods traditionally used for risk assessment. Significant progress has been made toward the adoption of NAMs for human health and environmental toxicity assessment. However, additional efforts are needed to expand their development and their use in regulatory decision making. A virtual symposium was held during the 2021 Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) Smoke Science and Product Technology (SSPT) conference (titled “Advancing New Alternative Methods for Tobacco Harm Reduction”), with the goals of introducing the concepts and potential application of NAMs in the evaluation of potentially reduced-risk (PRR) tobacco products. At the symposium, experts from regulatory agencies, research organizations, and NGOs shared insights on the status of available tools, strengths, limitations, and opportunities in the application of NAMs using case examples from safety assessments of chemicals and tobacco products. Following seven presentations providing background and application of NAMs, a discussion was held where the presenters and audience discussed the outlook for extending the NAMs toxicological applications for tobacco products. The symposium, endorsed by the CORESTA In Vitro Tox Subgroup, Biomarker Subgroup, and NextG Tox Task Force, illustrated common ground and interest in science-based engagement across the scientific community and stakeholders in support of tobacco regulatory science. Highlights of the symposium are summarized in this paper.
Journal	Toxics
Volume Number	10
PubMed Central reference number	PMC9781465
Issue Number	12
PubMed reference number	36548593
e-ISSN	23056304
DOI	10.3390/toxics10120760
Language	English
Publisher	MDPI
Publisher Date	2022-12-06
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	NAMS tobacco harm reduction integrated approaches
Content Type	Text
Resource Type	Article
Subject	Chemical Health and Safety Health, Toxicology and Mutagenesis Toxicology