NDLI: Metal-Organic Frameworks as Intelligent Drug Nanocarriers for Cancer Therapy.

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Metal-Organic Frameworks as Intelligent Drug Nanocarriers for Cancer Therapy.

Content Provider	Europe PMC
Author	Cai, Xuechao Bao, Xiaogang Wu, Yelin
Editor	Ficai, Anton Ficai, Denisa
Copyright Year	2022
Abstract	Metal–organic frameworks (MOFs) are crystalline porous materials with periodic network structures formed by self–assembly of metal ions and organic ligands. Attributed to their tunable composition and pore size, ultrahigh surface area (1000–7000 m2/g) and pore volume (1.04–4.40 cm3/g), easy surface modification, appropriate physiological stability, etc., MOFs have been widely used in biomedical applications in the last two decades, especially for the delivery of bioactive agents. In the initial stage, MOFs were widely used to load small molecule drugs with ultra–high doses. Whereafter, more recent work has focused on the load of biomacromolecules, such as nucleic acids and proteins. Over the past years, we have devoted extensive effort to investigate the function of MOF materials for bioactive agent delivery. MOFs can be used not only as an intelligent nanocarrier to deliver or protect bioactive agents but also as an activator for their release or activation in response to the different microenvironments. Altogether, this review details the current progress of MOF materials for bioactive agent delivery and looks into their future development.
Journal	Pharmaceutics
Volume Number	14
PubMed Central reference number	PMC9781098
Issue Number	12
PubMed reference number	36559134
e-ISSN	19994923
DOI	10.3390/pharmaceutics14122641
Language	English
Publisher	MDPI
Publisher Date	2022-11-29
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	metal–organic frameworks (MOFs) nanoMOFs drug delivery nanomedicine cancer therapy
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

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