NDLI: Endoplasmic Reticulum Stress in Hepatitis B Virus and Hepatitis C Virus Infection.

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Endoplasmic Reticulum Stress in Hepatitis B Virus and Hepatitis C Virus Infection.

Content Provider	Europe PMC
Author	Hu, Tengyue Wang, Jiayi Li, Weixiu Liu, Miao Han, Ning Yuan, Man Du, Lingyao Tang, Hong
Editor	Wang, Lin Lu, Fengmin
Copyright Year	2022
Abstract	Endoplasmic reticulum (ER) stress, a type of cellular stress, always occurs when unfolded or misfolded proteins accumulating in the ER exceed the protein folding capacity. Because of the demand for rapid viral protein synthesis after viral infection, viral infections become a risk factor for ER stress. The hepatocyte is a cell with large and well-developed ER, and hepatitis virus infection is widespread in the population, indicating the interaction between hepatitis viruses and ER stress may have significance for managing liver diseases. In this paper, we review the process that is initiated by the hepatocyte through ER stress against HBV and HCV infection and explain how this information can be helpful in the treatment of HBV/HCV-related diseases.
Journal	Viruses
Volume Number	14
PubMed Central reference number	PMC9780809
Issue Number	12
PubMed reference number	36560634
e-ISSN	19994915
DOI	10.3390/v14122630
Language	English
Publisher	MDPI
Publisher Date	2022-11-25
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	hepatitis B virus hepatitis C virus endoplasmic reticulum stress unfolded protein response
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology

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