NDLI: More than Just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network.

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More than Just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network.

Content Provider	Europe PMC
Author	Kuczyńska, Monika Jakubek, Patrycja Bartoszek, Agnieszka
Editor	Napolitano, Alessandra Jacob, Claus
Copyright Year	2022
Abstract	The concept of oxidative stress as a condition underlying a multitude of human diseases has led to immense interest in the search for antioxidant-based remedies. The simple and intuitive story of “the bad” reactive oxygen species (ROS) and “the good” antioxidants quickly (and unsurprisingly) lead to the commercial success of products tagged “beneficial to health” based solely on the presence of antioxidants. The commercial success of antioxidants by far preceded the research aimed at understanding the exact redox-related mechanisms that are in control of shaping the states of health and disease. This review describes the redox network formed by the interplay of ROS with cellular molecules and the resulting regulation of processes at the genomic and proteomic levels. Key players of this network are presented, both involved in redox signalling and control of cellular metabolism linked to most, if not all, physiological processes. In particular, this review focuses on the concept of reductive stress, which still remains less well-established compared to oxidative stress.
Journal	Antioxidants (Basel, Switzerland)
Volume Number	11
PubMed Central reference number	PMC9774234
Issue Number	12
PubMed reference number	36552611
e-ISSN	20763921
DOI	10.3390/antiox11122403
Language	English
Publisher	MDPI
Publisher Date	2022-12-04
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	redox homeostasis cellular signalling redox network reductive stress antioxidants
Content Type	Text
Resource Type	Article
Subject	Biochemistry Cell Biology Molecular Biology Physiology Clinical Biochemistry Food Science

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