A preliminary study on predictors of treatment response to repetitive transcranial magnetic stimulation in patients with treatment-resistant depression in Japan.

Content Provider	Europe PMC
Author	Ikawa, Haruki Tochigi, Mamoru Noda, Yoshihiro Oba, Hiroshi Kaminaga, Tatsuro Sakurai, Keita Ikebuchi, Emi Hayashi, Naoki Kunugi, Hiroshi
Abstract	AbstractBackgroundBrain imaging studies have reported that the effect of repetitive transcranial magnetic stimulation (rTMS) is associated with the activities of the dorsolateral prefrontal cortex (DLPFC) and ventral medial prefrontal cortex (VMPFC). However, few studies have been conducted in Japanese patients.AimWe aimed to identify brain regions associated with depressive symptom changes by measuring regional cerebral blood flow (rCBF) in the DLPFC and VMPFC before and after the high‐frequency rTMS to the left DLPFC in Japanese patients with treatment‐resistant depression.MethodFourteen patients participated in the rTMS study and were assessed with the 17‐item Hamilton depression rating scale (HAM‐D17). Among them, 13 participants underwent magnetic resonance imaging scan of the brain using the arterial spin labeling method. The rCBF was calculated using the fine stereotactic region of interest template (FineSRT) program for automated analysis. We focused on eight regions reported in previous studies.ResultsDepression severity significantly decreased after 2 week (HAM‐D17:11.4 ± 2.8, P = 0.00027) and 4 week (HAM‐D17: 11.0 ± 3.7, P = 0.0023) of rTMS treatment. There was no significant change in rCBF at each region in the pre‐post design. However, there was a significantly negative correlation between baseline rCBF in the right DLPFC and the improvement in HAM‐D17 score (r = −0.559, P = 0.047).ConclusionWe obtained supportive evidence for the effectiveness of rTMS to the prefrontal cortex in treatment‐resistant depression, which may be associated with reduced rCBF of the right DLPFC before initiation of rTMS.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9773710&blobtype=pdf
Page Count	7
Journal	Neuropsychopharmacology Reports [Neuropsychopharmacol Rep]
Volume Number	42
DOI	10.1002/npr2.12290
PubMed Central reference number	PMC9773710
Issue Number	4
PubMed reference number	36039823
e-ISSN	2574173X
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-08-30
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2022 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.
Subject Keyword	arterial spin labeling dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation treatment‐resistant depression ventrolateral prefrontal cortex
Content Type	Text
Resource Type	Article
Subject	Clinical Psychology Pharmacology Pharmacology (medical) Psychiatry and Mental Health