Loading...
Please wait, while we are loading the content...
Similar Documents
Intraoperative electron radiation therapy after salvage surgery in gynecological cancers and retroperitoneal sarcomas: outcomes and adverse effects.
| Content Provider | Europe PMC |
|---|---|
| Author | Oses, Gabriela Biete, Albert Muñoz-Guglielmetti, Diego Cases, Carla Barreto, Tanny Daniela Rovirosa, Angeles Torné, Aureli Pahisa, Jaume Fusté, Pere Rull, Ramón Herreros, Antonio Sáez, Jordi Mollà, Meritxell |
| Copyright Year | 2022 |
| Abstract | BackgroundSalvage surgery is considered an option for isolated recurrences of retroperitoneal and pelvic tumors, in patients who have undergone previous radiotherapy. In order to increase local control intra operative electron radiation therapy (IOERT) can be used in these patients to administer additional radiation dose. We evaluated the outcomes and adverse effects in patients with retroperitoneal sarcoma and gynecologic tumors after salvage surgery and IOERT.Materials and methodsTwenty patients were retrospectively analyzed. Twenty-three IOERT treatments were performed after surgery. Six (30%) were sarcoma and 14 (70%) were gynecological carcinoma. Administered dose depended on previous dose received with external beam radiotherapy (EBRT) and proximity to critical structures. The toxicities were scored using the Common Terminology Criteria for Adverse Events version 4.0.ResultsThe median age of the patients was 51 years (range 34–70). After a median follow-up of 32 months (range 1–68), in the sarcoma group the local control rate was 66.6%; while in the gynecological group the local control rate was 64.3%. In relation to late toxicity, one patient had a Grade 2 vesicovaginal fistula, and one patient presented Grade 4 enterocolitis and enteric intestinal fistula.ConclusionsIOERT could have a role in the treatment of retroperitoneal sarcomas in primary tumors after EBRT, as it may suggest a benefit in local control or recurrences after surgical resection in those at high risk of microscopic residual disease. The addition of IOERT to salvage resection for isolated recurrence of gynecologic cancers suggest favorable local control in cases with concern for residual microscopic disease. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9746645&blobtype=pdf |
| ISSN | 15071367 |
| Journal | Reports of Practical Oncology and Radiotherapy [Rep Pract Oncol Radiother] |
| Volume Number | 27 |
| PubMed Central reference number | PMC9746645 |
| Issue Number | 5 |
| PubMed reference number | 36523812 |
| e-ISSN | 20834640 |
| DOI | 10.5603/rpor.a2022.0099 |
| Language | English |
| Publisher | Via Medica |
| Publisher Date | 2022-10-31 |
| Access Restriction | Open |
| Rights License | This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially © 2022 Greater Poland Cancer Centre |
| Subject Keyword | retroperitoneal sarcoma gynecologic tumors intraoperative radiation therapy IOERT local recurrence toxicity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Cancer Research Oncology |
