Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy.

Content Provider	Europe PMC
Author	Pielorz, Sonia Węglińska, Magdalena Mazurek, Sylwester Szostak, Roman
Editor	Mavromoustakos, Thomas
Copyright Year	2022
Abstract	Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. Based on Raman and infrared reflection spectra of powdered tablets in the mid- and near-infrared regions and results of reference high-performance liquid chromatographic analysis, partial least squares models that enable fast and reliable quantification of the studied active ingredient in tablets, without the need for extraction, were elaborated. Eight commercial preparations containing diosmin in the 66-92% (w/w) range were analyzed. In order to assess and compare the quality of the developed chemometric models, the relative standard errors of prediction for calibration and validation sets were calculated. We found these errors to be in the 1.0-2.4% range for the three spectroscopic techniques used. Diosmin content in the analyzed preparations was obtained with recoveries in the 99.5-100.5% range.
Journal	Molecules
Volume Number	27
DOI	10.3390/molecules27238276
PubMed Central reference number	PMC9740429
Issue Number	23
PubMed reference number	36500369
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2022-11-27
Access Restriction	Open
Subject Keyword	diosmin Raman infrared NIR quantitative analysis pharmaceutical preparations PCA PLS
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry