NDLI: Electrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of <i>N</i>-Aryl Isoindolinones.

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Electrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of N-Aryl Isoindolinones.

Content Provider	Europe PMC
Author	Morlacci, Valerio Caruso, Tonino Chiarini, Marco Arcadi, Antonio Aschi, Massimiliano Palombi, Laura
Editor	Xu, Haichao
Copyright Year	2022
Abstract	An electrochemical initiated tandem reaction of anilines with 2-formyl benzonitrile has been developed. Thus, unprecedented 3-N-aryl substituted isoindolinones have been conveniently achieved by constant current electrolysis in a divided cell using catalytic amount of electricity and supporting electrolyte and a Pt-cathode as working electrode. The origin of the electrochemical activation as well as the mechanism of the subsequent chemical cascade reactions have been investigated by DFT calculations.
Journal	Molecules
Volume Number	27
DOI	10.3390/molecules27238199
PubMed Central reference number	PMC9738245
Issue Number	23
PubMed reference number	36500288
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2022-11-24
Access Restriction	Open
Subject Keyword	electrochemical synthesis anilines isoindolinone imine formation DFT
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry

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