NDLI: Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous System Diseases.

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Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous System Diseases.

Content Provider	Europe PMC
Author	Silvestri, Beatrice Mochi, Michela Garone, Maria Giovanna Rosa, Alessandro
Editor	Jellinger, Kurt A.
Copyright Year	2022
Abstract	The main goal of this review is to provide an updated overview of the involvement of the RNA-binding protein (RBP) HuD, encoded by the ELAVL4 gene, in nervous system development, maintenance, and function, and its emerging role in nervous system diseases. A particular focus is on recent studies reporting altered HuD levels, or activity, in disease models and patients. Substantial evidence suggests HuD involvement in Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). Interestingly, while possible disease-causing mutations in the ELAVL4 gene remain elusive, a common theme in these diseases seems to be the altered regulation of HuD at multiple steps, including post-transcriptional and post-translational levels. In turn, the changed activity of HuD can have profound implications for its target transcripts, which are overly stabilized in case of HuD gain of function (as proposed in PD and ALS) or reduced in case of decreased HuD binding (as suggested by some studies in AD). Moreover, the recent discovery that HuD is a component of pathological cytoplasmic inclusion in both familial and sporadic ALS patients might help uncover the common molecular mechanisms underlying such complex diseases. We believe that deepening our understanding of the involvement of HuD in neurodegeneration could help developing new diagnostic and therapeutic tools.
Journal	International Journal of Molecular Sciences [Int J Mol Sci]
Volume Number	23
DOI	10.3390/ijms232314606
PubMed Central reference number	PMC9736382
Issue Number	23
PubMed reference number	36498933
e-ISSN	14220067
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2022-11-23
Access Restriction	Open
Subject Keyword	HuD amyotrophic lateral sclerosis Alzheimer’s disease Parkinson’s disease RNA-binding protein ELAVL4
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications Medicine Inorganic Chemistry Organic Chemistry

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