NDLI: Ruthenium-Catalyzed Monoselective C-H Methylation and <i>d</i> <sub>3</sub>-Methylation of Arenes.

Please wait, while we are loading the content...

Ruthenium-Catalyzed Monoselective C-H Methylation and d ₃-Methylation of Arenes.

Content Provider	Europe PMC
Author	Hogg, Ashley Wheatley, Matthew Domingo-Legarda, Pablo Carral-Menoyo, Asier Cottam, Naomi Larrosa, Igor
Copyright Year	2022
Abstract	Site-selective installation of C–Me bonds remainsa powerfuland sought-after tool to alter the chemical and pharmacological propertiesof a molecule. Direct C–H functionalization provides an attractivemeans of achieving this transformation. Such protocols, however, typicallyutilize harsh conditions and hazardous methylating agents with poorapplicability toward late-stage functionalization. Furthermore, highlymonoselective methylation protocols remain scarce. Herein, we reportan efficient monoselective, directed ortho-methylationof arenes using N,N,N-trimethylanilinium salts asnoncarcinogenic, bench-stable methylating agents. We extend this protocolto d3-methylation in addition to the late-stagefunctionalization of pharmaceutically active compounds. Detailed kineticstudies indicate the rate-limiting in situ formation of MeI is integralto the observed reactivity.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9709947&blobtype=pdf
Journal	JACS Au
Volume Number	2
DOI	10.1021/jacsau.2c00399
PubMed Central reference number	PMC9709947
Issue Number	11
PubMed reference number	36465534
e-ISSN	26913704
Language	English
Publisher	American Chemical Society
Publisher Date	2022-10-21
Access Restriction	Open
Rights License	Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2022 The Authors. Published by American Chemical Society
Subject Keyword	catalysis ruthenium methylation C−H activation late-stage functionalization ammonium salts
Content Type	Text
Resource Type	Article
Subject	Chemistry Physical and Theoretical Chemistry Analytical Chemistry Organic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Ruthenium-Catalyzed Monoselective C-H Methylation and d 3-Methylation of Arenes.

Ruthenium-Catalyzed Monoselective C-H Methylation and d ₃-Methylation of Arenes.