The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children.

Content Provider	Europe PMC
Author	İpek, Sevcan Güllü, Ufuk Utku Güngör, Şükrü Demiray, Şeyma
Abstract	AimsIn this study, cardiac biomarkers, blood parameters, electrocardiography (ECG), and echocardiography were investigated in children with carbon monoxide (CO) poisoning, and the diagnostic value of these parameters was investigated.MethodsThe demographical, clinical, and laboratory data of children aged 0–18 years who were admitted to the pediatric emergency department due to CO poisoning between January 2019 and January 2022 were retrospectively scanned from medical records. The patients were divided into two groups as troponin-I positive and troponin-I negative.ResultsThere were 107 children aged 0–18 years (average age, 10.46 ± 5.77 years; 51% female) with CO poisoning. There were 13 patients with troponin-I positive myocardial injury. Troponin-I was positive in 3 patients whose carboxyhemoglobin (COHb) level was below 2% at the time of admission. In one patient, troponin-I, which was normal at admission, increased by the 24th hour of hospitalization. Hyperbaric oxygen therapy was given due to headache in one patient, although the COHb level of that patient was below 25%. An NT-proBNP level of ≥ 219.5 ng/L predicted the development of troponin-I positivity with a sensitivity of 70% and a specificity of 86.7% (AUC, 0.967 (0.58–0.994); p = 0.017). White blood cell (WBC), neutrophil, neutrophil-to-lymphocyte ratio (NLR), immature granulocyte (IG), and IG% levels were found to be significantly higher in the troponin-positive patient group.Discussion and conclusionNT-proBNP has been shown to be an early diagnostic marker for myocardial dysfunction. Additionally, when cardiac markers are not available, full blood parameters may assist clinicians for patient treatment and referral.
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ISSN	00211265
Journal	Irish Journal of Medical Science [Ir J Med Sci]
DOI	10.1007/s11845-022-03232-2
PubMed Central reference number	PMC9707252
PubMed reference number	36445626
e-ISSN	18634362
Language	English
Publisher	Springer International Publishing
Publisher Date	2022-11-29
Publisher Place	Gewerbestrasse 11, Cham, Ch 6330, Switzerland
Access Restriction	Open
Rights License	This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. © The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Subject Keyword	Blood Carbon monoxide poisoning Carboxyhemoglobin NT-proBNP Pediatric emergency department Troponin-I
Content Type	Text
Resource Type	Article
Subject	Medicine