Efficacy and safety of Tonifying Qi and activating blood Chinese herbal prescriptions for myocardial infarction: Study protocol for a multi-centered RCT.

Content Provider	Europe PMC
Author	Shang, Juju Qiu, Shenglei Zhou, Yingjie Liu, Sina Wang, Zi Lai, Xiaolei Liu, Hongxu Zhou, Mingxue Zhang, Zhenmin Liu, Pengyu Zhang, Fangfang Meng, Xianghui
Copyright Year	2022
Abstract	Introduction:Acute myocardial infarction (AMI) is a common cause of death worldwide and heart failure (HF) is the main complication. Although the increase in percutaneous coronary intervention and drug treatment can reduce in-hospital mortality after AMI, the incidence of HF after AMI and the resulting risk of death are still rising, which causes difficulties in the rehabilitation of AMI patients after reperfusion.Methods:In this prospective, multicenter, randomized, double-blind, double-dummy, placebo-controlled trial, we will assigned 673 eligible patients with AMI after reperfusion into 4 groups: receiving Nao-Xin-Tong capsule (NXT), Bu-Yang-Huan-Wu (BYHW) granule (BYHW), Yang-Yin-Tong-Nao granule (YYTN), or placebo. The course of treatment will be 3 months. The primary outcome is HF incidence within 180 days. Nao-Xin-Tong capsule, BYHW granule, and Yang-Yin-Tong-Nao granule are different traditional Chinese medicines used for tonifying Qi and activating blood (TQAB).Results:Three months of TQAB combined with Western medicine may reduce the incidence of HF after reperfusion of AMI and improve patients’ quality of life.Discussion:This study will provide an important basis for the application of traditional Chinese medicine in patients with AMI after reperfusion and provide an evidence-based basis for the prevention and treatment strategy of HF after AMI.
ISSN	00257974
Journal	Medicine
Volume Number	101
PubMed Central reference number	PMC9704927
Issue Number	47
PubMed reference number	36451469
e-ISSN	15365964
DOI	10.1097/md.0000000000031680
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2022-11-01
Publisher Place	Hagerstown, MD
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
Subject Keyword	acute myocardial infarction heart failure protocol Tonifying Qi and activating blood circulation traditional Chinese medicine
Content Type	Text
Resource Type	Article
Subject	Medicine