NDLI: Simple synthesis of multi-halogenated alkenes from 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane).

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Simple synthesis of multi-halogenated alkenes from 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane).

Content Provider	Europe PMC
Author	Karuo, Yukiko Tarui, Atsushi Sato, Kazuyuki Kawai, Kentaro Omote, Masaaki
Editor	Chen, David Yu-Kai
Copyright Year	2022
Abstract	A series of aryl fluoroalkenyl ethers that contain chlorine and bromine as well as fluorine atoms were prepared in moderate to good yields via the reactions of phenols and 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane) in the presence of KOH. This simple reaction enabled the construction of highly halogenated compounds with the potential for further functionalization. The reaction involved a highly reactive difluoroethylene intermediate, which was produced by the reaction between halothane and KOH.
Volume Number	18
PubMed Central reference number	PMC9704012
PubMed reference number	36483094
Journal	Beilstein Journal of Organic Chemistry [Beilstein J Org Chem]
e-ISSN	18605397
DOI	10.3762/bjoc.18.167
Language	English
Publisher	Beilstein-Institut
Publisher Date	2022-11-21
Publisher Place	Germany
Access Restriction	Open
Rights License	This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material. Copyright © 2022, Karuo et al.
Subject Keyword	aryl 1-monofluorovinyl ether electrophilic 1,1-difluoroethene halothane multi-halogenated alkene phenol
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry

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