NDLI: Marine Macrolides to Tackle Antimicrobial Resistance of <i>Mycobacterium tuberculosis</i>.

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Marine Macrolides to Tackle Antimicrobial Resistance of Mycobacterium tuberculosis.

Content Provider	Europe PMC
Author	Mamada, Sukamto S. Nainu, Firzan Masyita, Ayu Frediansyah, Andri Utami, Rifka Nurul Salampe, Mirnawati Emran, Talha Bin Lima, Clara Mariana Gonçalves Chopra, Hitesh Simal-Gandara, Jesus
Editor	Festa, Carmen Marino, Simona De
Copyright Year	2022
Abstract	Tuberculosis has become a major health problem globally. This is worsened by the emergence of resistant strains of Mycobacterium tuberculosis showing ability to evade the effectiveness of the current antimycobacterial therapies. Therefore, the efforts carried out to explore new entities from many sources, including marine, are critical. This review summarizes several marine-derived macrolides that show promising activity against M. tuberculosis. We also provide information regarding the biosynthetic processes of marine macrolides, including the challenges that are usually experienced in this process. As most of the studies reporting the antimycobacterial activities of the listed marine macrolides are based on in vitro studies, the future direction should consider expanding the trials to in vivo and clinical trials. In addition, in silico studies should also be explored for a quick screening on marine macrolides with potent activities against mycobacterial infection. To sum up, macrolides derived from marine organisms might become therapeutical options for tackling antimycobacterial resistance of M. tuberculosis.
Journal	Marine Drugs
Volume Number	20
PubMed Central reference number	PMC9697125
Issue Number	11
PubMed reference number	36355013
e-ISSN	16603397
DOI	10.3390/md20110691
Language	English
Publisher	MDPI
Publisher Date	2022-11-01
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	antimicrobial resistance Mycobacterium tuberculosis structure–activity relationship marine macrolides tuberculosis
Content Type	Text
Resource Type	Article
Subject	Pharmacology, Toxicology and Pharmaceutics Drug Discovery Pharmaceutical Science

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