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Activity-Based Fluorescent Probes Based on Hemicyanine for Biomedical Sensing.
| Content Provider | Europe PMC |
|---|---|
| Author | Luo, Pan Wang, Min Liu, Wenguang Liu, Lin Xu, Peng |
| Editor | Henary, Maged |
| Copyright Year | 2022 |
| Abstract | In recent years, fluorescent probes, as an analytical tool that can target and rapidly detect analytes, have been increasingly used for applications related to medical treatment, detection, and bioimaging. Researchers are interested in hemicyanine-based fluorescent probes because of their high quantum yield, tunable spectrum characteristics, absorption and emission in the near-infrared (NIR) region, and good photo-stability. The development of these dyes and their derivatives as NIR fluorescent probes for biological applications has advanced significantly in the last ten years. This review introduces processes for making hemicyanine dyes and the methodology for creating functional activity-based fluorescent probes. A variety of hemicyanine-based probes have been systematically developed for the detection of small biomolecules in various illnesses. Finally, the potential drawbacks of hemicyanine-based functional probes, and the prospects for future research and translation into clinical medicine, are also discussed. This study is intended to provide strategies for the development and design of novel fluorescence probes. |
| Journal | Molecules |
| Volume Number | 27 |
| DOI | 10.3390/molecules27227750 |
| PubMed Central reference number | PMC9695617 |
| Issue Number | 22 |
| PubMed reference number | 36431849 |
| e-ISSN | 14203049 |
| Language | English |
| Publisher | Molecular Diversity Preservation International (MDPI) |
| Publisher Date | 2022-11-10 |
| Access Restriction | Open |
| Subject Keyword | hemicyanine fluorescent probe imaging sensing analytical tool |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry |
