Potentially Beneficial Effects on Healthy Aging by Supplementation of the EPA-Rich Microalgae Phaeodactylum tricornutum or Its Supernatant-A Randomized Controlled Pilot Trial in Elderly Individuals.

Content Provider	Europe PMC
Author	Stiefvatter, Lena Frick, Konstantin Lehnert, Katja Vetter, Walter Montoya-Arroyo, Alexander Frank, Jan Schmid-Staiger, Ulrike Bischoff, Stephan C.
Editor	Tommonaro, Giuseppina Tramice, Annabella
Copyright Year	2022
Abstract	Dietary supplements that promote healthy aging are mostly warranted in an aging society. Because of age-related risks, anti-inflammatory and anti-oxidative agents such as microalgae are potential candidates for intervention. In a randomized controlled trial, we tested Phaeodactylum tricornutum (PT), a microalgae rich in eicosapentaenoic acid (EPA), carotenoids, vitamins, and β-glucans, cultured in bioreactors. In this pilot trial, 19 healthy elderly received supplements for two weeks based on either the whole PT (A), the β-1,3-glucan-rich PT supernatant (SupB), the combination thereof (A+SupB), or a Comparator product (Comp). The primary outcome variable plasma interleukin-6 was reduced after treatment with A+SupB compared to the Comp group (p = 0.04). The mobility parameters 5 s sit-to-stand test (p = 0.04 in the A group) and by trend gait speed (p = 0.08 in the A+SupB diet) were improved compared to Comp. No treatment effects were observed for fatty acids, compared to Comp but omega-6 to -3 fatty acid ratio (p = 0.006) and arachidonic acid/EPA ratio (p = 0.006) were reduced within group A+SupB. Further, the SupB study product reduced faecal zonulin (p = 0.03) compared to the Comp. The data revealed an anti-inflammatory and potentially anti-oxidative effect of particular PT preparations, suggesting that they might be suitable for effects in healthy elderly.
Journal	Marine Drugs
Volume Number	20
PubMed Central reference number	PMC9694444
Issue Number	11
PubMed reference number	36421994
e-ISSN	16603397
DOI	10.3390/md20110716
Language	English
Publisher	MDPI
Publisher Date	2022-11-15
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	elderly inflammageing Phaeodactylum tricornutum omega-3-fatty acids eicosapentaenoic acid fucoxanthin β-glucan chrysolaminarin
Content Type	Text
Resource Type	Article
Subject	Pharmacology, Toxicology and Pharmaceutics Drug Discovery Pharmaceutical Science