NDLI: Enhanced Delivery of Insulin through Acrylamide-Modified Chitosan Containing Smart Carrier System.

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Enhanced Delivery of Insulin through Acrylamide-Modified Chitosan Containing Smart Carrier System.

Content Provider	Europe PMC
Author	Dahan, Wasmia Mohammed Mohammad, Faruq Ezzat, AbdelRahman O. Atta, Ayman M. Al-Tilasi, Hissah Hamad Al-Lohedan, Hamad A.
Editor	Shi, Junfeng Xu, Fei Dinu, Maria Valentina
Copyright Year	2022
Abstract	The present study develops on insulin-release studies from the chitosan-amide-modified stimuli-responsive polymers formed from various fatty acids including stearic acid, oleic acid, linoleic acid, and linolenic acid. This is the continuation of an earlier reported study that investigates the insulin-release profiles of chitosan-modified fatty acid amides (without stimuli responsive polymers). Following the synthesis and characterization of many different fatty acid amides with a varying amount of unsaturation, the insulin drug loading and release effects were compared among N-isopropylacrylamide (NIPAm), a thermo-responsive polymer, and 2-acrylamide-2-methylpropane sulfonic acid (AMPS), a pH-responsive polymer-modified hydrogel that is expected to enhance environmental response and the controllability of release. Finally, drug release effects were studied to investigate the drug release mechanisms with the help of five different pharmacokinetic models including the zero-order, first-order, Higuchi, Korsmeyers–Peppas, and Hixson models. The results indicate that the Higuchi and Hixson models are valid in terms of the operation of the NIPAm and AMPS matrices during the delivery of insulin.
Journal	Gels
Volume Number	8
PubMed Central reference number	PMC9689140
Issue Number	11
PubMed reference number	36354609
e-ISSN	23102861
DOI	10.3390/gels8110701
Language	English
Publisher	MDPI
Publisher Date	2022-10-30
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	insulin delivery modified chitosan pH-based release N-isopropylacrylamide (NIPAm) 2-acrylamide-2-methylpropane sulfonic acid (AMPS) drug release kinetics
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomaterials Polymers and Plastics Organic Chemistry

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