Peptide-Based Supramolecular Hydrogels as Drug Delivery Agents: Recent Advances.

Content Provider	Europe PMC
Author	Oliveira, Carlos B. P. Gomes, Valéria Ferreira, Paula M. T. Martins, José A. Jervis, Peter J.
Editor	Kuckling, Dirk Van Vlierberghe, Sandra
Copyright Year	2022
Abstract	Supramolecular peptide hydrogels have many important applications in biomedicine, including drug delivery applications for the sustained release of therapeutic molecules. Targeted and selective drug administration is often preferential to systemic drug delivery, as it can allow reduced doses and can avoid the toxicity and side-effects caused by off-target binding. New discoveries are continually being reported in this rapidly developing field. In this review, we report the latest developments in supramolecular peptide-based hydrogels for drug delivery, focusing primarily on discoveries that have been reported in the last four years (2018–present). We address clinical points, such as peptide self-assembly and drug release, mechanical properties in drug delivery, peptide functionalization, bioadhesive properties and drug delivery enhancement strategies, drug release profiles, and different hydrogel matrices for anticancer drug loading and release.
Journal	Gels
Volume Number	8
PubMed Central reference number	PMC9689023
Issue Number	11
PubMed reference number	36354614
e-ISSN	23102861
DOI	10.3390/gels8110706
Language	English
Publisher	MDPI
Publisher Date	2022-11-01
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	hydrogel peptide drug delivery controlled release stimuli-responsive cancer therapy supramolecular smart materials biomaterials
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomaterials Polymers and Plastics Organic Chemistry