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Role of Translationally Controlled Tumor Protein (TCTP) in the Development of Hypertension and Related Diseases in Mouse Models.
| Content Provider | Europe PMC |
|---|---|
| Author | Maeng, Jeehye Lee, Kyunglim |
| Editor | Zicha, Josef Vaněčková, Ivana |
| Copyright Year | 2022 |
| Abstract | Translationally controlled tumor protein (TCTP) is a multifunctional protein that plays a wide variety of physiological and pathological roles, including as a cytoplasmic repressor of Na,K-ATPase, an enzyme pivotal in maintaining Na+ and K+ ion gradients across the plasma membrane, by binding to and inhibiting Na,K-ATPase. Studies with transgenic mice overexpressing TCTP (TCTP-TG) revealed the pathophysiological significance of TCTP in the development of systemic arterial hypertension. Overexpression of TCTP and inhibition of Na,K-ATPase result in the elevation of cytoplasmic Ca2+ levels, which increases the vascular contractility in the mice, leading to hypertension. Furthermore, studies using an animal model constructed by multiple mating of TCTP-TG with apolipoprotein E knockout mice (ApoE KO) indicated that TCTP-induced hypertension facilitates the severity of atherosclerotic lesions in vivo. This review attempts to discuss the mechanisms underlying TCTP-induced hypertension and related diseases gleaned from studies using genetically altered animal models and the potential of TCTP as a target in the therapy of hypertension-related pathological conditions. |
| Journal | Biomedicines |
| Volume Number | 10 |
| PubMed Central reference number | PMC9687121 |
| Issue Number | 11 |
| PubMed reference number | 36359240 |
| e-ISSN | 22279059 |
| DOI | 10.3390/biomedicines10112722 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-10-27 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors. |
| Subject Keyword | ApoE KO apolipoprotein E knockout mice atherosclerosis hypertension Na,K-ATPase TCTP TCTP-overexpressing transgenic mice translationally controlled tumor protein TCTP-TG |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
