Maternal Subclinical Hyperthyroidism and Adverse Pregnancy Outcomes: A Systematic Review and Meta-analysis of Observational Studies.

Content Provider	Europe PMC
Author	Nazarpour, Sima Amiri, Mina Bidhendi Yarandi, Razieh Azizi, Fereidoun Ramezani Tehrani, Fahimeh
Copyright Year	2022
Abstract	ContextFindings from studies evaluating adverse pregnancy outcomes in pregnant women with subclinical hyperthyroidism are conflicting and inconclusive.ObjectivesIn this systematic review and meta-analysis, our aim was to evaluate the pooled odds ratio (OR) of adverse pregnancy outcomes in women with subclinical hyperthyroidism, compared to euthyroid women.Data SourcesScopus, PubMed (including Medline), and Web of Science databases were systemically searched for regaining published studies to January 2022 examining adverse pregnancy outcomes in women with subclinical hyperthyroidism.Study SelectionOutcomes of interest were classified into seven composite outcomes, including hypertensive disorders, preterm delivery, macrosomia/large for gestational age (LGA), pregnancy loss, adverse maternal outcomes, adverse neonatal outcomes, and adverse fetal outcomes.Data ExtractionIn this meta-analysis, both fixed and random effect models were used. Publication bias was also evaluated by Egger test and the funnel plot, and the trim and fill method was conducted in case of a significant result, to adjust the bias.ResultsOf 202 records retrieved through searching databases, 11 studies were selected for the final analyses. There were no significant differences in pooled ORs of hypertensive disorders, preterm delivery, macrosomia/LGA, and pregnancy loss in pregnant women with subclinical hyperthyroidism, compared to the euthyroid controls. The pooled OR of adverse maternal, neonatal, and fetal outcomes in pregnant women with subclinical hyperthyroidism was not statistically significantly different from that of the euthyroid control group.ConclusionsThe current meta-analysis demonstrated that subclinical hyperthyroidism in pregnancy is not related with adverse maternal and fetal outcomes. Therefore, clinicians should be avoided unnecessary treatments for pregnant women with subclinical hyperthyroidism.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9675093&blobtype=pdf
ISSN	1726913X
Journal	International Journal of Endocrinology and Metabolism [Int J Endocrinol Metab]
Volume Number	20
DOI	10.5812/ijem-120949
PubMed Central reference number	PMC9675093
Issue Number	3
PubMed reference number	36425270
e-ISSN	17269148
Language	English
Publisher	Brieflands
Publisher Date	2022-07-19
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. Copyright © 2022, International Journal of Endocrinology and Metabolism
Subject Keyword	Subclinical Hyperthyroidism Pregnancy Outcomes Systematic Review Meta-analysis
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism