NDLI: Multiple-Streams Focusing-Based Cell Separation in High Viscoelasticity Flow.

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Multiple-Streams Focusing-Based Cell Separation in High Viscoelasticity Flow.

Content Provider	Europe PMC
Author	Feng, Haidong Patel, Dhruv Magda, Jules J. Geher, Sage Sigala, Paul A. Gale, Bruce K.
Copyright Year	2022
Abstract	Viscoelastic flow has been widely used in microfluidicparticleseparation processes, in which particles get focused on the channelcenter in diluted viscoelastic flow. In this paper, the transitionfrom single-stream focusing to multiple-streams focusing (MSF) inhigh viscoelastic flow is observed, which is applied for cell separationprocesses. Particle focusing stream bifurcation is caused by the balancebetween elastic force and viscoelastic secondary flow drag force.The influence of cell physical properties, such as cell dimension,shape, and deformability, on the formation of multiple-streams focusingis studied in detail. Particle separation is realized utilizing differentseparation criteria. The size-based separation of red (RBC) and white(WBC) blood cells is demonstrated in which cells get focused in differentstreams based on their dimension difference. Cells with differentdeformabilities get stretched in the viscoelastic flow, leading tothe change of focusing streams, and this property is harnessed toseparate red blood cells infected with the malaria parasite, Plasmodium falciparum. The achieved results promoteour understanding of particle movement in the high viscoelastic flowand enable new particle manipulation and separation processes forsample treatment in biofluids.
Journal	ACS Omega
Volume Number	7
PubMed Central reference number	PMC9670260
Issue Number	45
PubMed reference number	36406492
e-ISSN	24701343
DOI	10.1021/acsomega.2c06021
Language	English
Publisher	American Chemical Society
Publisher Date	2022-11-02
Access Restriction	Open
Rights License	Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). © 2022 The Authors. Published by American Chemical Society
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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