Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma.

Content Provider	Europe PMC
Author	Eker, Çağlar İnan, Hakkı Caner Çelebi, Asuman Gözen, Emine Deniz Karaman, Emin
Copyright Year	2022
Abstract	Objective: Despite all the recent advancements, larynx cancer has shown no improvement in survival rates. The aim of this study was to investigate the expressions of toll-like receptor (TLR)-2, -3, and -4 genes, and determine any relationships with the histopathologic characteristics of the disease. Methods: This retrospective study included 50 subjects who underwent total or partial laryngectomy with an open surgical method for larynx squamous cell carcinoma. Measurements of TLRs-2, -3, and -4 expression values were taken with quantitative real time-polymerase chain reaction in normal tissue and tumor tissue samples of the patients. Results: Evaluations were made of TLR-2, -3, and -4 mRNA expressions according to 2-ΔΔCT calculations in 50 subjects with larynx cancer. When the tumor tissue was compared with the healthy tissue from the same subjects, reductions were determined in TLR expression in 86%, 84%, and 82%, respectively. This reduction in each gene expression was statistically significant (p<0.001). No statistically significant correlation was determined between the change in TLR-2, -3, and -4 expression and the histopathologic characteristics of the disease. Conclusion: The data obtained in this study demonstrated that TLR-2, -3, and -4 expressions were reduced in larynx squamous cell cancer. The results of further studies targeting these genes would be useful in the diagnosis and treatment of the disease.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9667699&blobtype=pdf
ISSN	26677466
Volume Number	60
DOI	10.4274/tao.2022.2022-6-17
PubMed Central reference number	PMC9667699
Issue Number	3
PubMed reference number	36452243
Journal	Turkish Archives of Otorhinolaryngology [Turk Arch Otorhinolaryngol]
e-ISSN	26677474
Language	English
Publisher	Galenos Publishing
Publisher Date	2022-09-01
Access Restriction	Open
Rights License	Content of this journal is licensed under a Creative Commons Attribution 4.0 International License. ©Copyright 2022 by Official Journal of the Turkish Society of Otorhinolaryngology and Head and Neck Surgery
Subject Keyword	Larynx cancer toll-like receptors gene expression squamous cell carcinoma tumor microenvironment
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology