Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal Ions.

Content Provider	Europe PMC
Author	Jarczewska, Marta Szymczyk, Anna Zajda, Joanna Olszewski, Marcin Ziółkowski, Robert Malinowska, Elżbieta
Editor	Galeone, Aldo
Copyright Year	2022
Abstract	Recently nucleic acids gained considerable attention as selective receptors of metal ions. This is because of the possibility of adjusting their sequences in new aptamers selection, as well as the convenience of elaborating new detection mechanisms. Such a flexibility allows for easy utilization of newly emerging nanomaterials for the development of detection devices. This, in turn, can significantly increase, e.g., analytical signal intensity, both optical and electrochemical, and the same can allow for obtaining exceptionally low detection limits and fast biosensor responses. All these properties, together with low power consumption, make nucleic acids biosensors perfect candidates as detection elements of fully automatic portable microfluidic devices. This review provides current progress in nucleic acids application in monitoring environmentally and clinically important metal ions in the electrochemical or optical manner. In addition, several examples of such biosensor applications in portable microfluidic devices are shown.
Journal	Molecules
Volume Number	27
DOI	10.3390/molecules27217481
PubMed Central reference number	PMC9657803
Issue Number	21
PubMed reference number	36364308
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2022-11-02
Access Restriction	Open
Subject Keyword	aptamers nucleic acids metal ions electrochemistry optical detection methods nanomaterials microflow devices
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry