Not to Rush-Laboratory Parameters and Procedural Complications in Patients Undergoing Left Atrial Appendage Closure.

Content Provider	Europe PMC
Author	Zweiker, David Fiedler, Lukas Toth, Gabor G. Strouhal, Andreas Delle-Karth, Georg Stix, Guenter Gabriel, Harald Binder, Ronald K. Rammer, Martin Pfeffer, Michael Vock, Paul Lileg, Brigitte Steinwender, Clemens Sihorsch, Kurt Hintringer, Florian Mueller, Silvana Barbieri, Fabian Martinek, Martin Tkalec, Wolfgang Verheyen, Nicolas Ablasser, Klemens Zirlik, Andreas Scherr, Daniel
Editor	Unterhuber, Matthias Lucà, Fabiana
Copyright Year	2022
Abstract	Background: As a preventive procedure, minimizing periprocedural risk is crucially important during left atrial appendage closure (LAAC). Methods: We included consecutive patients receiving LAAC at nine centres and assessed the relationship between baseline characteristics and the acute procedural outcome. Major procedural complications were defined as all complications requiring immediate invasive intervention or causing irreversible damage. Logistic regression was performed and included age and left-ventricular function. Furthermore, the association between acute complications and long-term outcomes was evaluated. Results: A total of 405 consecutive patients with a median age of 75 years (37% female) were included. 47% had a history of stroke. Median CHA2DS2-VASc score was 4 (interquartile range, 3−5) and the median HAS-BLED score was 3 (2−4). Major procedural complications occurred in 7% of cases. Low haemoglobin (OR 0.8, 95% CI 0.65−0.99 per g/dL, p = 0.040) and end-stage kidney disease (OR 13.0, CI 2.5−68.5, p = 0.002) remained significant in multivariate analysis. Anaemia (haemoglobin < 12 and < 13 g/dL in female and male patients) increased the risk of complications 2.2-fold. Conclusions: The major complication rate was low in this high-risk patient population undergoing LAAC. End-stage kidney disease and low baseline haemoglobin were independently associated with a higher major complication rate.
Journal	Journal of Clinical Medicine [J Clin Med]
Volume Number	11
DOI	10.3390/jcm11216548
PubMed Central reference number	PMC9656817
Issue Number	21
PubMed reference number	36362774
e-ISSN	20770383
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2022-11-04
Access Restriction	Open
Subject Keyword	left atrial appendage closure atrial fibrillation complications haemoglobin dialysis
Content Type	Text
Resource Type	Article
Subject	Medicine