NDLI: The Role of <i>Fusobacterium nucleatum</i> in Colorectal Cancer Cell Proliferation and Migration.

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The Role of Fusobacterium nucleatum in Colorectal Cancer Cell Proliferation and Migration.

Content Provider	Europe PMC
Author	Wu, Zihong Ma, Qiong Guo, Ying You, Fengming
Editor	Abou-Kheir, Wassim Bahmad, Hisham
Copyright Year	2022
Abstract	Simple SummaryAlthough the promoting roles of the epithelial–mesenchymal transition (EMT), tumor microenvironment (TME), and oncogenic ncRNAs in tumor metastasis have been fully verified, the mechanisms by which Fusobacterium nucleatum (Fn) contributes to the progression of colorectal cancer (CRC) remain poorly understood. The main scope of the current work is to summarize the potential molecular mechanisms by which Fn promotes the proliferation and migration of CRC cells by affecting biological processes, such as EMT, TME, and oncogenic ncRNAs. The ultimate goal is to provide a possible strategy for effective CRC treatment in the near future.AbstractColorectal cancer (CRC) is a common cancer worldwide with poor prognosis. The presence of Fusobacterium nucleatum (Fn) in the intestinal mucosa is associated with the progression of CRC. In this review, we explore the mechanisms by which Fn contributes to proliferation and migration of CRC cells from the following four aspects: induction of the epithelial–mesenchymal transition (EMT), regulation of the tumor microenvironment (TME), expression of oncogenic noncoding RNAs, and DNA damage. This review outlines the scientific basis for the use of Fn as a biomarker and therapeutic target in CRC.
Journal	Cancers
Volume Number	14
PubMed Central reference number	PMC9656216
Issue Number	21
PubMed reference number	36358769
e-ISSN	20726694
DOI	10.3390/cancers14215350
Language	English
Publisher	MDPI
Publisher Date	2022-10-30
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	colorectal cancer Fusobacterium nucleatum proliferation and migration epithelial–mesenchymal transition tumor microenvironment
Content Type	Text
Resource Type	Article
Subject	Oncology Cancer Research

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