Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results.

Content Provider	Europe PMC
Author	Arifian, Hanggara Maharani, Rani Megantara, Sandra Gazzali, Amirah Mohd Muchtaridi, Muchtaridi
Editor	Lungu, Claudiu N. Mangalagiu, Ionel
Copyright Year	2022
Abstract	Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the fact that amino acids are important building blocks of life and are abundantly available; thus, a greater shift can result in structural modification, since amino acids contain a variety of sidechains. This review discusses the data available on amino acid-natural compound conjugates that were reported with respect to their backgrounds, the synthetic approach and their bioactivity. Several amino acid-natural compound conjugates have shown enhanced pharmacokinetic characteristics, including absorption and distribution properties, reduced toxicity and increased physiological effects. This approach could offer a potentially effective system of drug discovery that can enable the development of pharmacologically active and pharmacokinetically acceptable molecules.
Journal	Molecules
Volume Number	27
DOI	10.3390/molecules27217631
PubMed Central reference number	PMC9654077
Issue Number	21
PubMed reference number	36364457
e-ISSN	14203049
Language	English
Publisher	Molecular Diversity Preservation International (MDPI)
Publisher Date	2022-11-07
Access Restriction	Open
Subject Keyword	natural compounds amino acid conjugation chemical synthesis
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Medicine Chemistry Drug Discovery Pharmaceutical Science Analytical Chemistry Molecular Medicine Organic Chemistry