Salmonella enteritis Spondylitis with Brucella melitensis Infection: A Rare Case of Mixed Infections of Spine.

Content Provider	Europe PMC
Author	Zhang, WenSheng Wang, Jie Zhang, Yao Ma, Rui Zhang, Qiang
Copyright Year	2022
Abstract	BackgroundAs a widespread back condition in orthopedics, spondylitis is rarely caused by Salmonella. Here, we report a rare case of spondylitis caused by Salmonella enteritis associated with Brucella melitensis.Case PresentationSalmonella septicemia was initially diagnosed in a 27-year-old woman with high fever and low back pain, but her symptoms did not improve after 3 days of antibiotic treatment. The patient was then referred to our hospital’s Department of Infectious Diseases. This patient had mild anemia. There were no positive results for tuberculosis antibody and Rose Bengal plate agglutination (RBPT). When the patient’s symptoms did not improve after diagnostic anti-tuberculosis treatment, he was transferred to our Orthopaedics department for lumbar posterior lesion removal, decompression, internal fixation, cage implantation, and bone grafting fusion under general anesthesia. Following the operation, a postoperative specimen culture and a real-time polymerase chain reaction (real-time-PCR) indicated Salmonella enteritis with Brucella melitensis (B. melitensis) infection. The symptoms improved and inflammatory markers returned to normal after 2 weeks of treatment with levofloxacin, rifampicin, and doxycycline.ConclusionAnaemic patients with immunocompromised conditions should be given special attention in the diagnosis of Salmonella spondylitis. Surgery should be considered if antibiotic therapy fails to identify the pathogen that is infecting the patient with infectious spondylitis.
Page Count	7
Volume Number	15
PubMed Central reference number	PMC9651031
PubMed reference number	36386422
Journal	Infection and Drug Resistance [Infect Drug Resist]
e-ISSN	11786973
DOI	10.2147/IDR.S385759
Language	English
Publisher	Dove
Publisher Date	2022-11-07
Access Restriction	Open
Rights License	This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). © 2022 Zhang et al.
Subject Keyword	Salmonella brucellosis spondylitis mixed infection
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Infectious Diseases Pharmacology