Clickable Polymer Ligand-Functionalized Iron Oxide Nanocubes: A Promising Nanoplatform for 'Local Hot Spots' Magnetically Triggered Drug Release.

Content Provider	Europe PMC
Author	Mai, Binh T. Conteh, John S. Gavilán, Helena Di Girolamo, Alessandro Pellegrino, Teresa
Copyright Year	2022
Abstract	Exploiting the localheat on the surface of magneticnanoparticles(MNPs) upon exposure to an alternating magnetic field (AMF) to cleavethermal labile bonds represents an interesting approach in the contextof remotely triggered drug delivery. Here, taking advantages of asimple and scalable two-step ligand exchange reaction, we have preparediron oxide nanocubes (IONCs) functionalized with a novel multifunctionalpolymer ligand having multiple catechol moieties, furfuryl pendants,and polyethylene glycol (PEG) side chains. Catechol groups ensurea strong binding of the polymer ligands to the IONCs surface, whilethe PEG chains provide good colloidal stability to the polymer-coatedIONCs. More importantly, furfuryl pendants on the polymer enable toclick the molecules of interest (either maleimide–fluoresceinor maleimide–doxorubicin) via a thermal labile Diels–Alderadduct. The resulting IONCs functionalized with a fluorescein/doxorubicin-conjugatedpolymer ligand exhibit good colloidal stability in buffer saline andserum solution along with outstanding heating performance in aqueoussolution or even in viscous media (81% glycerol/water) when exposedto the AMF of clinical use. The release of conjugated bioactive moleculessuch as fluorescein and doxorubicin could be boosted by applying AMFconditions of clinical use (16 kAm–1 and 110 kHz).It is remarkable that the magnetic hyperthermia-mediated release ofthe dye/drug falls in the concentration range 1.0–5.0 μMat an IONCs dose as low as 0.5 gFe/L and at no macroscopicaltemperature change. This local release effect makes this magneticnanoplatform a potential tool for drug delivery with remote magnetichyperthermia actuation and with a dose-independent action of MNPs.
ISSN	19448244
Journal	ACS Applied Materials & Interfaces
Volume Number	14
PubMed Central reference number	PMC9634696
Issue Number	43
PubMed reference number	36256634
e-ISSN	19448252
DOI	10.1021/acsami.2c14752
Language	English
Publisher	American Chemical Society
Publisher Date	2022-10-18
Access Restriction	Open
Rights License	Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2022 The Authors. Published by American Chemical Society
Subject Keyword	multifunctional polymer heat-mediated release magnetic hyperthermia iron oxide nanoparticles drug release hot-spoteffect
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Materials Science